Firefighters battled a blaze at Castle Hotel located on Chapel Street, New Amsterdam, Berbice.
About 4:37 p.m., Water tenders #74 and #87, along with a Land Rover and their crews under the command of Divisional Officer Harry, promptly responded to the scene, with the first unit arriving at 4:40 p.m.
When they arrived the top floor of the three-storey building was engulfed in flames, while the second floor was destroyed.
There have been no reports of injuries and all occupants were reportedly safely evacuated from the building.